解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Notwithstanding the central biological role of the (6-4) photoadduct in the induction of skin cancer by sunlight, crucial mechanistic details about its formation have evaded characterization despite efforts spanning more than half a century. 4-Thiothymidine (4tT) has been widely used as an important model system to st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17333-y
更新日期:2020-07-17 00:00:00
abstract::Development of efficient catalysts for selective electroreduction of CO2 to high-value products is essential for the deployment of carbon utilization technologies. Here we present a scalable method for preparing Cu electrocatalysts that favor CO2 conversion to C2+ products with faradaic efficiencies up to 72%. Grazing...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16998-9
更新日期:2020-07-17 00:00:00
abstract::Polar van der Waals chalcogenophosphates exhibit unique properties, such as negative electrostriction and multi-well ferrielectricity, and enable combining dielectric and 2D electronic materials. Using low temperature piezoresponse force microscopy, we revealed coexistence of piezoelectric and non-piezoelectric phases...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17137-0
更新日期:2020-07-17 00:00:00
abstract::Standard units of measurement are required for the quantitative description of nature; however, few standard units have been established for genomics to date. Here, we have developed a synthetic DNA ladder that defines a quantitative standard unit that can measure DNA sequence abundance within a next-generation sequen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17445-5
更新日期:2020-07-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17430-y
更新日期:2020-07-16 00:00:00
abstract::The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern. It is imperative to identify these patients early. We show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical cha...
journal_title:Nature communications
pub_type: 杂志文章,多中心研究
doi:10.1038/s41467-020-17280-8
更新日期:2020-07-15 00:00:00
abstract::Van der Waals materials and heterostructures that manifest strongly bound exciton states at room temperature also exhibit emergent physical phenomena and are of great promise for optoelectronic applications. Here, we demonstrate that nanostructured, multilayer transition metal dichalcogenides (TMDCs) by themselves pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17313-2
更新日期:2020-07-15 00:00:00
abstract::Density functional theory (DFT) is the standard formalism to study the electronic structure of matter at the atomic scale. In Kohn-Sham DFT simulations, the balance between accuracy and computational cost depends on the choice of exchange and correlation functional, which only exists in approximate form. Here, we prop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17265-7
更新日期:2020-07-14 00:00:00
abstract::It is unclear whether the establishment of apical-basal cell polarity during the generation of epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here, we show that the I-BAR-containing IRSp53 protein controls lumen formation and the positioning of the polarity determinants aPKC and po...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17091-x
更新日期:2020-07-14 00:00:00
abstract::Artificial photosynthesis is a vibrant field of research aiming at converting abundant, low energy molecules such as water, nitrogen or carbon dioxide into fuels or useful chemicals by means of solar energy input. Photo-electrochemical reduction of carbon dioxide is an appealing strategy, aiming at reducing the greenh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17125-4
更新日期:2020-07-13 00:00:00
abstract::Conventional lithium-ion batteries embrace graphite anodes which operate at potential as low as metallic lithium, subjected to poor rate capability and safety issues. Among possible alternatives, oxides based on titanium redox couple, such as spinel Li4Ti5O12, have received renewed attention. Here we further expand th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17233-1
更新日期:2020-07-13 00:00:00
abstract::Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial energetics. We find that Slc44a2 null mic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17254-w
更新日期:2020-07-13 00:00:00
abstract::Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17212-6
更新日期:2020-07-13 00:00:00
abstract::Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica. Classical monocytes as well as testosterone are identified to have important functions for the development of hepatic amebiasis in mice, but a link between testosterone and monocy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17260-y
更新日期:2020-07-10 00:00:00
abstract::When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17287-1
更新日期:2020-07-10 00:00:00
abstract::Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage. However, little is known about genomic changes during natural colonisation. Here, we use whole-genome sequencing to investigate within-host microevolu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17327-w
更新日期:2020-07-10 00:00:00
abstract::We have determined the cryo-electron microscopic (cryo-EM) structures of two archaeal type IV pili (T4P), from Pyrobaculum arsenaticum and Saccharolobus solfataricus, at 3.8 Å and 3.4 Å resolution, respectively. This triples the number of high resolution archaeal T4P structures, and allows us to pinpoint the evolution...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17268-4
更新日期:2020-07-09 00:00:00
abstract::Accurately predicting chromatin loops from genome-wide interaction matrices such as Hi-C data is critical to deepening our understanding of proper gene regulation. Current approaches are mainly focused on searching for statistically enriched dots on a genome-wide map. However, given the availability of orthogonal data...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17239-9
更新日期:2020-07-09 00:00:00
abstract::COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymph...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17240-2
更新日期:2020-07-08 00:00:00
abstract::Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17318-x
更新日期:2020-07-08 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17071-1
更新日期:2020-07-07 00:00:00
abstract::Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell envelope, and are targets of anti-tuberculosis drug ethambutol. We present the 3.3 Å resolution single-particle cryo-electron microscopy structure of Mycobacteriu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17202-8
更新日期:2020-07-07 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17055-1
更新日期:2020-07-06 00:00:00
abstract::The mammary gland is a highly vascularized tissue capable of expansion and regression during development and disease. To enable mechanistic insight into the coordinated morphogenic crosstalk between the epithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mammary duct in proximit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17102-x
更新日期:2020-07-06 00:00:00
abstract::The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17317-y
更新日期:2020-07-06 00:00:00
abstract::Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms. Here we apply dual RNA-seq to Orientia tsutsugamushi (Ot), an obligate...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17094-8
更新日期:2020-07-03 00:00:00
abstract::TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17097-5
更新日期:2020-07-03 00:00:00
abstract::To avoid dangerous climate change, new technologies must remove billions of tonnes of CO2 from the atmosphere every year by mid-century. Here we detail a land-based enhanced weathering cycle utilizing magnesite (MgCO3) feedstock to repeatedly capture CO2 from the atmosphere. In this process, MgCO3 is calcined, produci...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16510-3
更新日期:2020-07-03 00:00:00
abstract::Earth's core is composed of iron (Fe) alloyed with light elements, e.g., silicon (Si). Its thermal conductivity critically affects Earth's thermal structure, evolution, and dynamics, as it controls the magnitude of thermal and compositional sources required to sustain a geodynamo over Earth's history. Here we directly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17106-7
更新日期:2020-07-03 00:00:00
abstract::The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on single-molecule struc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17141-4
更新日期:2020-07-03 00:00:00
abstract::As European heatwaves become more severe, summers in the United Kingdom (UK) are also getting warmer. The UK record temperature of 38.7 °C set in Cambridge in July 2019 prompts the question of whether exceeding 40 °C is now within reach. Here, we show how human influence is increasing the likelihood of exceeding 30, 3...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16834-0
更新日期:2020-06-30 00:00:00
abstract::No method exists to measure large-scale translation of genes in uncultured organisms in microbiomes. To overcome this limitation, we develop MetaRibo-Seq, a method for simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples. MetaRibo-Seq was benchmarked against gold-standard Ribo-Seq in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17081-z
更新日期:2020-06-29 00:00:00
abstract::BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer drivers, among which ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16936-9
更新日期:2020-06-26 00:00:00
abstract::Hybrid quantum systems are essential for the realization of distributed quantum networks. In particular, piezo-mechanics operating at typical superconducting qubit frequencies features low thermal excitations, and offers an appealing platform to bridge superconducting quantum processors and optical telecommunication c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17053-3
更新日期:2020-06-26 00:00:00
abstract::Bioorthogonal chemistry introduces affinity-labels into biomolecules with minimal disruption to the original system and is widely applicable in a range of contexts. In proteomics, immobilized metal affinity chromatography (IMAC) enables enrichment of phosphopeptides with extreme sensitivity and selectivity. Here, we a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17010-0
更新日期:2020-06-26 00:00:00
abstract::CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17029-3
更新日期:2020-06-26 00:00:00
abstract::The challenge of monitoring in planta dynamic changes of NADP(H) and NAD(H) redox states at the subcellular level is considered a major obstacle in plant bioenergetics studies. Here, we introduced two circularly permuted yellow fluorescent protein sensors, iNAP and SoNar, into Arabidopsis thaliana to monitor the dynam...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17056-0
更新日期:2020-06-26 00:00:00
abstract::Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 3...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17003-z
更新日期:2020-06-25 00:00:00
abstract::Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery cover...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16818-0
更新日期:2020-06-25 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) gen...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-020-16711-w
更新日期:2020-06-24 00:00:00